Optimal design and operation of reactive distillation systems based on a superstructure methodology

• Method for simultaneous optimisation of reactive distillation design and operation. Based on a superstructure approach. Consideration reaction versus separation characteristics. Investigation industrially relevant systems. A novel methodology the operation complex process, considering number process alternatives (e.g. pre-/side-reactor, side-stripper, additional columns etc.), is presented. The based approach, detailed cost-based objective function, solved by MINLP optimisation. illustrated using different case studies industrial interest with varying For easy separations, in terms relative volatilities boiling points order, single column found to be optimal both fast slower kinetics. However, when more challenging (i.e. product middle-boiler), complex, even kinetics, processing units, such as pre-reactor and/or columns, are required meet quality specifications. It that design, i.e. capital cost, mainly depends point rankings. operation, chemical equilibrium dominant factor. demonstrated, however, combined effects must considered carefully designing process. liquid holdup has an impact performance, proper choice can lead flexible able mitigate production failure issues reactions.